Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.

Cell cycle (Georgetown, Tex.) - 1 Sept 2005

Zerbini Luiz F, Wang Yihong, Correa Ricardo G, Cho Je-Yoel, Libermann Towia A

Abstract excerpt

The p53 tumor suppressor gene plays an important role during induction of apoptosis in cancer. In contrast, NF-kappaB prevents apoptosis in response to chemotherapeutic agents and is a critical regulator of cell survival. Despite the riches of information on the regulation of wild-type p53 function by phosphorylation, nothing is known about the modulation of mutant p53 activity by phosphorylation. Here we report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Anthracenes
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to MAP Kinase Kinase 4

Share to NF-kappa B

Share to Oligonucleotides

Share to Serine

Source

Identifiers

PMID: 16082226
DOI: 10.4161/cc.4.9.1966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.PMID 16082226Read ↗

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.Semantic proximity Read ↗

Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes.Semantic proximity Read ↗

Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.Semantic proximity Read ↗

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.Semantic proximity Read ↗

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase.Semantic proximity Read ↗

A role for ATR in the DNA damage-induced phosphorylation of p53.Semantic proximity Read ↗

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.Semantic proximity Read ↗

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.Semantic proximity Read ↗

PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-cateninSemantic proximity Read ↗

Activation of NF-κB by the Kaposi's Sarcoma-Associated Herpesvirus K15 Protein Involves Recruitment of the NF-κB-Inducing Kinase, IκB Kinases, and Phosphorylation of p65Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.