Article
Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice.
Genes, brain, and behavior - 1 Nov 2008
Houchi H, Warnault V, Barbier E, Dubois C, Pierrefiche O, Ledent C, Daoust M, Naassila M
Abstract excerpt
We have shown previously that mice lacking the adenosine A2A receptor (A2AR) generated on a CD1 background self-administer more ethanol and exhibit hyposensitivity to acute ethanol. We aimed to investigate if the increased propensity of A2A(-/-) mice to consume ethanol is associated with an altered sensitivity in the motivational properties of ethanol in the conditioned place preference (CPP) and conditioned...
Topics
- Adenosine
- Alcohol-Induced Disorders, Nervous System
- Animals
- Anti-Anxiety Agents
- Anxiety
- Behavior, Animal
- Brain
- Central Nervous System Depressants
- Conditioning, Psychological
- Disease Models, Animal
- Drug Resistance
- Ethanol
- Genotype