Article
Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Apr 2000
Rasmussen S K, Lautier C, Hansen L, Echwald S M, Hansen T, Ekstrøm C T, Urhammer S A, Borch-Johnsen K, Grigorescu F, Smith R J, Pedersen O
Abstract excerpt
Insulin-like growth factor I (IGF-I) is an important regulator of many aspects of growth, differentiation, and development, and as low birth weight has been associated with impaired glucose tolerance and overt type 2 diabetes in adult life, we considered the genes encoding the IGF-I and the IGF-I receptor (IGF-IR) as candidates for low birth weight, insulin resistance, and type 2 diabetes. Here we report the...
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