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Article

Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).

The Journal of clinical endocrinology and metabolism - 1 Jun 2002

Arends Nicolette, Johnston Linda, Hokken-Koelega Anita, van Duijn Cornelia, de Ridder Maria, Savage Martin, Clark Adrian

Abstract excerpt

Low birth weight is associated with an increased risk in adult life of type 2 diabetes, hypertension and cardiovascular disease (CVD). The fetal insulin hypothesis postulates that genes involving insulin resistance could effect birth weight and disease in later life (Hattersley, 1999). Besides insulin, there is extensive evidence that insulin-like growth factor-I and -II (IGF-I, IGF-II) play an important role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12050240
DOI: 10.1210/jcem.87.6.8673

Genes

SDS
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).PMID 12050240Read ↗

Polymorphism in the IGF-I Gene: Clinical Relevance for Short Children Born Small for Gestational Age (SGA)Semantic proximity Read ↗

The insulin-like growth factor-I (IGF-I) gene in individuals born small for gestational age (SGA).Semantic proximity Read ↗

The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children.Semantic proximity Read ↗

Association between insulin-like growth factor I (IGF-I) polymorphisms, circulating IGF-I, and pre- and postnatal growth in two European small for gestational age populations.Semantic proximity Read ↗

Association analysis of ten candidate genes in a large multinational cohort of small for gestational age children and children with idiopathic short stature (NESTEGG study).Semantic proximity Read ↗

The influence of INS VNTR class III allele on auxological parameters, glucose, insulin, lipids, and adipocytokines secretion in prepubertal children born small for gestational age.Semantic proximity Read ↗

Association between small for gestational age and paternally inherited 5' insulin haplotypes.Semantic proximity Read ↗

The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.Semantic proximity Read ↗

Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational AgeSemantic proximity Read ↗

Cardiovascular risk factors in parents of short children born small for gestational age.Semantic proximity Read ↗

Regulation of IGFBP3 gene expression in short children born small for gestational age.Semantic proximity Read ↗

Variation in the IGF1 gene and growth in foetal life and infancy. The Generation R Study.Semantic proximity Read ↗

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