Article

Polymorphism in the IGF-I Gene: Clinical Relevance for Short Children Born Small for Gestational Age (SGA)

2002-06-01

Abstract excerpt

Low birth weight is associated with an increased risk in adult life of type 2 diabetes, hypertension and cardiovascular disease (CVD). The fetal insulin hypothesis postulates that genes involving insulin resistance could effect birth weight and disease in later life (Hattersley, 1999). Besides insulin, there is extensive evidence that insulin-like growth factor-I and -II (IGF-I, IGF-II) play an important role in f...

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Literature Corpus work: 2499fb49-a075-5550-8606-44e990225ff6
DOI: 10.1210/jc.87.6.2720

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