Article
The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.
The Journal of clinical endocrinology and metabolism - 1 Apr 2000
Rasmussen S K, Urhammer S A, Jensen J N, Hansen T, Borch-Johnsen K, Pedersen O
Abstract excerpt
Recently, two G-->A polymorphisms at positions -308 and -238, in the promoter of the tumor necrosis factor alpha (TNF-alpha) gene, have been identified. These variants have, in different ethnic groups, been linked to estimates of insulin resistance and obesity. The objective of the present study was to investigate whether these genetic variants of TNF-alpha were associated with features of the insulin resistance...
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