Article
A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.
Diabetes - 1 May 1998
Vafiadis P, Grabs R, Goodyer C G, Colle E, Polychronakos C
Abstract excerpt
Genetic studies have identified a number of loci demonstrating linkage to type 1 diabetes. One of the largest single contributors to genetic susceptibility, after the major histocompatability complex, is the IDDM2 locus, which maps to a nontranscribed variable number of tandem repeats (VNTR) mini...
Topics
- Alleles
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Embryonic and Fetal Development
- Fathers
- Genetic Code
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Insulin-Like Growth Factor II
- Minisatellite Repeats
- Pancreas
- Polymerase Chain Reaction
- Thymus Gland
- Transcription, Genetic