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Article

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.

Diabetes - 1 May 1998

Vafiadis P, Grabs R, Goodyer C G, Colle E, Polychronakos C

Abstract excerpt

Genetic studies have identified a number of loci demonstrating linkage to type 1 diabetes. One of the largest single contributors to genetic susceptibility, after the major histocompatability complex, is the IDDM2 locus, which maps to a nontranscribed variable number of tandem repeats (VNTR) minisatellite upstream of the insulin (INS) and insulin-like growth factor 2 (IGF2) genes. In a progression from population...

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Source

Identifiers

PMID: 9588457
DOI: 10.2337/diabetes.47.5.831

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.PMID 9588457Read ↗

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.Semantic proximity Read ↗

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.Semantic proximity Read ↗

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.Semantic proximity Read ↗

IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy.Semantic proximity Read ↗

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcriptionSemantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes.Semantic proximity Read ↗

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