Article
The yeast p53 functional assay: a new tool for molecular epidemiology. Hopes and facts.
Mutation research - 1 Apr 2000
Fronza G, Inga A, Monti P, Scott G, Campomenosi P, Menichini P, Ottaggio L, Viaggi S, Burns P A, Gold B, Abbondandolo A
Abstract excerpt
The assumption of molecular epidemiology that carcinogens leave fingerprints has suggested that analysis of the frequency, type, and site of mutations in genes frequently altered in carcinogenesis may provide clues to the identification of the factors contributing to carcinogenesis. In this mini-review, we revise the development, and validation of the yeast-based p53 functional assay as a new tool for molecular...
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