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Article

Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay.

Nucleic acids research - 1 Mar 2001

Kovvali G K, Mehta B, Epstein C B, Lutzker S G

Abstract excerpt

Missense mutations within the central DNA binding region of p53 are the most prevalent mutations found in human cancer. Numerous studies indicate that 'hot-spot' p53 mutants (which comprise approximately 30% of human p53 gene mutations) are largely devoid of transcriptional activity. However, a g...

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Identifiers

PMID: 11222779
DOI: 10.1093/nar/29.5.e28
PMCID: PMC29741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11222779-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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