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Article

Functional analysis of chemically-induced mutations at the flounder TP53 locus, the FACIM assay.

Mutation research - 18 Aug 2004

Cachot J, Couteau J, Frébourg T, Leboulenger F, Flaman J-M

Abstract excerpt

A functional assay was developed in yeast to identify mutations induced by DNA-damaging agents at the flounder TP53 locus. This assay named FACIM for functional analysis of chemically-induced p53 mutations, is based on the assumption that most genotoxin-induced mutations inactivate transcriptional activity of the TP53 protein. The functional status of the protein expressed in yeast was measured using a...

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Share to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15288541
DOI: 10.1016/j.mrfmmm.2004.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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