Article
Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2006
Soussi Thierry, Asselain Bernard, Hamroun Dalil, Kato Shunsuke, Ishioka Chikashi, Claustres Mireille, Béroud Christophe
Abstract excerpt
PURPOSE: Analyses of the pattern of p53 mutations have been essential for epidemiologic studies linking carcinogen exposure and cancer. We were concerned by the inclusion of dubious reports in the p53 databases that could lead to controversial analysis prejudicial to the scientific community. EXPERIMENTAL DESIGN: We used the universal mutation database p53 database (21,717 mutations) combined with a new p53...
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