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Article

Caspase processing activates atypical protein kinase C zeta by relieving autoinhibition and destabilizes the protein.

The Biochemical journal - 1 Nov 2003

Smith Lucinda, Wang Zhi, Smith Jeffrey B

Abstract excerpt

Treatment of HeLa cells with tumour necrosis factor alpha (TNFalpha) induced caspase processing of ectopic PKC (protein kinase C) zeta, which converted most of the holoenzyme into the freed kinase domain and increased immune-complex kinase activity. The goal of the present study was to determine the basis for the increased kinase activity that is associated with caspase processing of PKC zeta. Atypical PKC iota...

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Identifiers

PMID: 12887331
DOI: 10.1042/BJ20030926
PMCID: PMC1223714

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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