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Article

Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.

Circulation research - 14 Apr 2000

Vatner D E, Yang G P, Geng Y J, Asai K, Yun J S, Wagner T E, Ishikawa Y, Bishop S P, Homcy C J, Vatner S F

Abstract excerpt

Mice with overexpressed cardiac Gsalpha develop cardiomyopathy, characterized by myocyte hypertrophy and extensive myocardial fibrosis. The cardiomyopathy likely involves chronically enhanced beta-adrenergic signaling, because it can be blocked with long-term propranolol treatment. It remains unknown whether the genotype of the myocyte is solely responsible for the progressive pathological changes. A chimeric...

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PMID: 10764415
DOI: 10.1161/01.res.86.7.802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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