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Article

Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor

1 Apr 2001

Abstract excerpt

Serum response factor (SRF), a member of the MCM1, agamous, deficiens, SRF (MADS) family of transcriptional activators, has been implicated in the transcriptional control of a number of cardiac muscle genes, including cardiac alpha-actin, skeletal alpha-actin, alpha-myosin heavy chain (alpha-MHC), and beta-MHC. To better understand the in vivo role of SRF in regulating genes responsible for maintenance of cardiac...

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PMID: 11247792
DOI: 10.1152/ajpheart.2001.280.4.h1782

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