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Article

Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy.

Circulation - 6 Jun 2006

Kim Yun-Kyung, Suarez Jorge, Hu Ying, McDonough Patrick M, Boer Christa, Dix David J, Dillmann Wolfgang H

Abstract excerpt

BACKGROUND: Hspa1a and Hspa1b genes encode stress-inducible 70-kDa heat shock proteins (Hsp70) that protect cells from insults such as ischemia. Mice with null mutations of both genes (KO) were generated, and their cardiac phenotype was explored. METHODS AND RESULTS: Heart rate and blood pressure...

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Identifiers

PMID: 16735677
DOI: 10.1161/CIRCULATIONAHA.105.598409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16735677-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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