Article
The loss of mdm2 induces p53-mediated apoptosis.
Oncogene - 23 Mar 2000
de Rozieres S, Maya R, Oren M, Lozano G
Abstract excerpt
The p53 tumor suppressor gene product is negatively regulated by the product of its downstream target, mdm2. The deletion of mdm2 in the mouse results in embryonic lethality at 5.5 days post coitum (d.p.c.) which can be overcome by simultaneous loss of the p53 tumor suppressor, substantiating the importance of the negative regulatory function of MDM2 on p53 function in vivo. Hence, the loss of MDM2 allowed the...
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