Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.

doi:10.1038/378206a0

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Article

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.

Nature - 9 Nov 1995

Jones S N, Roe A E, Donehower L A, Bradley A

Abstract excerpt

The Mdm2 proto-oncogene was originally identified as one of several genes contained on a mouse double minute chromosome present in a transformed derivative of 3T3 cells. Overexpression of Mdm2 can immortalize primary cultures of rodent fibroblasts. Human MDM2 is amplified in 30-40% of sarcomas, a...

Topics

3T3 Cells
Animals
Base Sequence
Cell Cycle
Cell Line
Crosses, Genetic
DNA Primers
Embryonic and Fetal Development
Female
Gene Targeting
Genes, Lethal
Mice
Molecular Sequence Data
Mutation
Nuclear Proteins
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

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