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Article

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.

Nature - 9 Nov 1995

Jones S N, Roe A E, Donehower L A, Bradley A

Abstract excerpt

The Mdm2 proto-oncogene was originally identified as one of several genes contained on a mouse double minute chromosome present in a transformed derivative of 3T3 cells. Overexpression of Mdm2 can immortalize primary cultures of rodent fibroblasts. Human MDM2 is amplified in 30-40% of sarcomas, and is overexpressed in leukaemic cells. The Mdm2 oncoprotein forms a complex with the p53 tumour-suppressor protein and...

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Identifiers

PMID: 7477327
DOI: 10.1038/378206a0

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.PMID 7477327Read ↗

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Semantic proximity Read ↗

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.Semantic proximity Read ↗

Mdm proteins: critical regulators of embryogenesis and homoeostasisSemantic proximity Read ↗

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.Semantic proximity Read ↗

Mdm2 and Mdm4 loss regulates distinct p53 activities.Semantic proximity Read ↗

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.Semantic proximity Read ↗

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesisSemantic proximity Read ↗

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.Semantic proximity Read ↗

Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.Semantic proximity Read ↗

Distinct downstream targets manifest p53-dependent pathologies in mice.Semantic proximity Read ↗

The role of MDM2 and MDM4 in breast cancer development and preventionSemantic proximity Read ↗

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish.Semantic proximity Read ↗

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