Article
Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene.
Cancer research - 15 Mar 2006
Dudgeon Crissy, Kek Calvina, Demidov Oleg N, Saito Shin-ichi, Fernandes Kenneth, Diot Alexandra, Bourdon Jean-Christophe, Lane David P, Appella Ettore, Fornace Albert J, Bulavin Dmitry V
Abstract excerpt
Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable with wild-type murine p53; however, transactivation, induction of apoptosis, and G(1)-S checkpoint, but not transrepression or regulation of a centrosomal checkpoint,...
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