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Article

Evidence for a new Graves disease susceptibility locus at chromosome 18q21.

American journal of human genetics - 1 May 2000

Vaidya B, Imrie H, Perros P, Young E T, Kelly W F, Carr D, Large D M, Toft A D, Kendall-Taylor P, Pearce S H

Abstract excerpt

Graves disease (GD) is a common autoimmune thyroid disorder that is inherited as a complex multigenic trait. By using a single microsatellite marker at each locus, we screened the type 1 diabetes loci IDDM4, IDDM5, IDDM6, IDDM8, and IDDM10 and the fucosyltransferase-2 locus for linkage in sib pairs with GD. This showed a two-point nonparametric linkage (NPL) score of 1.57 (P=.06) at the IDDM6 marker D18S41, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10762555
DOI: 10.1086/302908
PMCID: PMC1378028

Genes

NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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