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Article

Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions.

The Journal of clinical endocrinology and metabolism - 1 Dec 1999

Tomer Y, Barbesino G, Greenberg D A, Concepcion E, Davies T F

Abstract excerpt

The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of a complex interaction between predisposing genes and environmental triggers. The goals of the present study were to identify the susceptibility loci for GD and HT and to study the relationships between them. We performed a whole genome linkage study on a dataset of 56...

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PMID: 10599734
DOI: 10.1210/jcem.84.12.6216

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