Frequent integration of precore/core mutants of hepatitis B virus in human hepatocellular carcinoma tissues.

doi:10.1046/j.1365-2893.2000.00209.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Frequent integration of precore/core mutants of hepatitis B virus in human hepatocellular carcinoma tissues.

Journal of viral hepatitis - 1 Mar 2000

Zhong S, Chan J Y, Yeo W, Tam J S, Johnson P J

Abstract excerpt

The development of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) frequently follows persistent HBV infection and may arise in individuals who are hepatitis B e antigen (HBeAg) negative, indicating the possible presence of precore/core mutants. It is unclear whether precore/core mutants are associated with tumour development or are selected for after chromosomal integration of the wild-type...

Topics

Adult
Aged
Amino Acid Sequence
Base Sequence
Blotting, Southern
Carcinoma, Hepatocellular
Child
Female
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Humans
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10760041
DOI: 10.1046/j.1365-2893.2000.00209.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics