Article
Association between hepatitis B virus core promoter rearrangements and hepatocellular carcinoma.
Biochemical and biophysical research communications - 27 Mar 1998
Laskus T, Radkowski M, Nowicki M, Wang L F, Vargas H, Rakela J
Abstract excerpt
Hepatitis B virus (HBV) is the major etiological agent of hepatocellular carcinoma (HCC). Whether any particular viral variants are associated with HCC is unknown. We studied 53 Gambian patients with HCC and 33 HBsAg positive controls. A functional part of HBV core promoter and whole precore regi...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Gambia
- Hepatitis B
- Hepatitis B Core Antigens
- Humans
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Prospective Studies
- Sequence Deletion
- Virus Integration