Article
Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma.
Journal of gastroenterology and hepatology - 1 Sept 2016
Zhang An-Ye, Lai Ching-Lung, Poon Ronnie Tung-Ping, Huang Fung-Yu, Seto Wai-Kay, Fung James, Wong Danny Ka-Ho, Yuen Man-Fung
Abstract excerpt
BACKGROUND AND AIM: Hepatitis B virus (HBV) full-length genomic mutations and quasispecies characteristics in hepatocellular carcinoma (HCC) were investigated. METHODS: Hepatitis B virus DNA was extracted from the tumor and non-tumor tissues of 16 HCC patients. Overlapping DNA fragments covering the entire HBV genome were amplified and sequenced. To study HBV sequence at the quasispecies level, the preS region...
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