Article
Inflammatory bowel disease: progress toward a gene.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie - 1 Mar 2000
van Heel D A, Satsangi J, Carey A H, Jewell D P
Abstract excerpt
The pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD) is still unknown, but the importance of genetic susceptibility has been clearly shown by epidemiological data from family and twin studies. Linkage studies have identified two susceptibility loci for inflammatory bowel disease (IBD) on chromosomes 12 and 16. Importantly, these linkages have been replicated by independent investigators, and...
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