Article
Towards a molecular risk map--recent advances on the etiology of inflammatory bowel disease.
Seminars in immunology - 1 Dec 2009
Rosenstiel Philip, Sina Christian, Franke Andre, Schreiber Stefan
Abstract excerpt
Recent advances have enabled a comprehensive understanding of the genetic architecture of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The pathophysiological consequences of disease gene variants in Crohn disease and ulcerative colitis, the two main subentities of IBD, so far are only understood on the single disease gene level, yet complex network analyses linking the...
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