Article
Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.
Expert review of clinical immunology - 1 Oct 2016
Ye Byong Duk, McGovern Dermot P B
Abstract excerpt
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broadened our understanding of the genetic architecture of IBD. Currently, over 200 single nucleotide...
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