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Article

Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype.

Carcinogenesis - 1 Apr 2000

Delfino R J, Sinha R, Smith C, West J, White E, Lin H J, Liao S Y, Gim J S, Ma H L, Butler J, Anton-Culver H

Abstract excerpt

Breast cancer risk has been hypothesized to increase with exposure to heterocyclic aromatic amines (HAAs) formed from cooking meat at high temperature. HAAs require enzymatic activation to bind to DNA and initiate carcinogenesis. N-acetyltransferase 2 (NAT2) enzyme activity may play a role, its rate determined by a polymorphic gene. We examined the effect of NAT2 genetic polymorphisms on breast cancer risk from...

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Identifiers

PMID: 10753193
DOI: 10.1093/carcin/21.4.607

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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