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Article

Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.

Gut - 1 Mar 2013

Voutsinas Jenna, Wilkens Lynne R, Franke Adrian, Vogt Thomas M, Yokochi Lance A, Decker Robert, Le Marchand Loïc

Abstract excerpt

OBJECTIVE: Heterocyclic amines (HAA) are animal carcinogens that are present in meat cooked at high temperature and in tobacco smoke. These compounds require activation by cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase-2 (NAT2) before they can damage DNA. This study tested the hypotheses that well-done meat and cigarette smoking increase the risk of adenoma, the precursor to most colorectal cancers,...

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Source

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Identifiers

PMID: 22628494
DOI: 10.1136/gutjnl-2011-300665
PMCID: PMC4491437

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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