Article
N-acetyltransferase 2, exposure to aromatic and heterocyclic amines, and receptor-defined breast cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Mar 2010
Rabstein Sylvia, Brüning Thomas, Harth Volker, Fischer Hans-Peter, Haas Susanne, Weiss Tobias, Spickenheuer Anne, Pierl Christiane, Justenhoven Christina, Illig Thomas, Vollmert Caren, Baisch Christian, Ko Yon-Dschun, Hamann Ute, Brauch Hiltrud, Pesch Beate
Abstract excerpt
The role of N-acetyltransferase 2 (NAT2) polymorphism in breast cancer is still unclear. We explored the associations between potential sources of exposure to aromatic and heterocyclic amines (AHA), acetylation status and receptor-defined breast cancer in 1020 incident cases and 1047 population controls of the German GENICA study. Acetylation status was assessed as slow or fast. Therefore, NAT2 haplotypes were...
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