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Article

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.

The Journal of biological chemistry - 26 May 2000

Gong D W, Monemdjou S, Gavrilova O, Leon L R, Marcus-Samuels B, Chou C J, Everett C, Kozak L P, Li C, Deng C, Harper M E, Reitman M L

Abstract excerpt

Uncoupling protein-3 (UCP3) is a mitochondrial protein that can diminish the mitochondrial membrane potential. Levels of muscle Ucp3 mRNA are increased by thyroid hormone and fasting. Ucp3 has been proposed to influence metabolic efficiency and is a candidate obesity gene. We have produced a Ucp3 knockout mouse to test these hypotheses. The Ucp3 (-/-) mice had no detectable immunoreactive UCP3 by Western...

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Source

Identifiers

PMID: 10748195
DOI: 10.1074/jbc.M910177199

Genes

UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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