Article
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
Nature - 27 Jul 2000
Clapham J C, Arch J R, Chapman H, Haynes A, Lister C, Moore G B, Piercy V, Carter S A, Lehner I, Smith S A, Beeley L J, Godden R J, Herrity N, Skehel M, Changani K K, Hockings P D, Reid D G, Squires S M, Hatcher J, Trail B, Latcham J, Rastan S, Harper A J, Cadenas S, Buckingham J A, Brand M D, Abuin A
Abstract excerpt
Uncoupling protein-3 (UCP-3) is a recently identified member of the mitochondrial transporter superfamily that is expressed predominantly in skeletal muscle. However, its close relative UCP-1 is expressed exclusively in brown adipose tissue, a tissue whose main function is fat combustion and thermogenesis. Studies on the expression of UCP-3 in animals and humans in different physiological situations support a...
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