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Article

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.

Diabetologia - 1 Aug 2001

Dalgaard L T, Pedersen O

Abstract excerpt

Uncoupling proteins are mitochondrial carrier proteins which are able to dissipate the proton gradient of the inner mitochondrial membrane. This uncoupling process reduces the amount of ATP generated through an oxidation of fuels. The hypothesis that uncoupling proteins (UCPs) are candidate genes for human obesity or Type II (non-insulin-dependent) diabetes mellitus is based on the finding that a chemical...

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Source

Identifiers

PMID: 11484071
DOI: 10.1007/s001250100596

Genes

UCP1
UCP2
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.PMID 11484071Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

Role of the Polymorphisms of Uncoupling Protein Genes in Childhood Obesity and Their Association with Obesity-Related Disturbances.Semantic proximity Read ↗

The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.Semantic proximity Read ↗

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)Semantic proximity Read ↗

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.Semantic proximity Read ↗

The influence of six polymorphisms of uncoupling protein 3 (UCP3) gene and childhood obesity: a case-control study.Semantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese.Semantic proximity Read ↗

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.Semantic proximity Read ↗

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsideredSemantic proximity Read ↗

Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects.Semantic proximity Read ↗

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