Article
Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.
European journal of endocrinology - 1 May 2008
van Abeelen Annet F M, de Krom Mariken, Hendriks Judith, Grobbee Diederick E, Adan Roger A H, van der Schouw Yvonne T
Abstract excerpt
OBJECTIVE: Uncoupling protein 3 (UCP-3) uncouples oxidative metabolism from ATP synthesis, resulting in the production of heat instead of energy storage. Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat. DESIGN: We conducted a population-based, cross-sectional single-center study among 400...
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