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Article

Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.

Human molecular genetics - 15 Nov 2012

Wells Timothy, Davies Jennifer R, Guschina Irina A, Ball Daniel J, Davies Jeffrey S, Davies Vanessa J, Evans Bronwen A J, Votruba Marcela

Abstract excerpt

The interrelationship between brown adipose tissue (BAT) and white adipose tissue (WAT) is emerging as an important factor in obesity, but the effect of impairing non-shivering thermogenesis in BAT on lipid storage in WAT remains unclear. To address this, we have characterized the metabolic phenotype of a mouse model for Costeff syndrome, in which a point mutation in the mitochondrial membrane protein Opa3...

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Share to Abdominal Fat
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22869679
DOI: 10.1093/hmg/dds315

Genes

UCP1

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