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Article

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

Diabetes - 1 Feb 2000

Boss O, Hagen T, Lowell B B

Abstract excerpt

Mitochondria use energy derived from fuel combustion to create a proton electrochemical gradient across the mitochondrial inner membrane. This intermediate form of energy is then used by ATP synthase to synthesize ATP. Uncoupling protein-1 (UCP1) is a brown fat-specific mitochondrial inner membrane protein with proton transport activity. UCP1 catalyzes a highly regulated proton leak, converting energy stored...

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Source

Identifiers

PMID: 10868929
DOI: 10.2337/diabetes.49.2.143

Genes

UCP1
UCP2
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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