Article
The energetic implications of uncoupling protein-3 in skeletal muscle.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme - 1 Oct 2007
Costford Sheila R, Seifert Erin L, Bézaire Véronic, F Gerrits Martin, Bevilacqua Lisa, Gowing Adrienne, Harper Mary-Ellen
Abstract excerpt
Despite almost a decade of research since the identification of uncoupling protein-3 (UCP3), the molecular mechanisms and physiological functions of this mitochondrial anion carrier protein are not well understood. Because of its highly selective expression in skeletal muscle and the existence of mitochondrial proton leak in this tissue, early reports proposed that UCP3 caused a basal proton leak and increased...
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