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MCM2 in human cancer: functions, mechanisms, and clinical significance

27 Oct 2022

Abstract excerpt

BACKGROUND: Aberrant DNA replication is the main source of genomic instability that leads to tumorigenesis and progression. MCM2, a core subunit of eukaryotic helicase, plays a vital role in DNA replication. The dysfunction of MCM2 results in the occurrence and progression of multiple cancers through impairing DNA replication and cell proliferation. CONCLUSIONS: MCM2 is a vital regulator in DNA replication. The...

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PMID: 36303105
DOI: 10.1186/s10020-022-00555-9

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