Article
Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Bettinotti M P, Norris R D, Hackett J A, Thompson C O, Simonis T B, Stroncek D, Marincola F M
Abstract excerpt
The analysis of immune responses of patients with melanoma has led to the identification of melanoma-associated antigens targeted by T cells. Cytotoxic T lymphocytes recognize peptides from melanoma-associated antigens presented on the cancer cell surface in the context of HLA class I molecules. Immunodominant melanoma-associated antigen epitopes are being evaluated for their ability to immunize patients with...
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