Article
HLA-independent heterogeneity of CD8+ T cell responses to MAGE-3, Melan-A/MART-1, gp100, tyrosinase, MC1R, and TRP-2 in vaccine-treated melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998
Reynolds S R, Celis E, Sette A, Oratz R, Shapiro R L, Johnston D, Fotino M, Bystryn J C
Abstract excerpt
An important element in melanoma vaccine construction is to identify peptides from melanoma-associated Ags that have immunogenic potential in humans and are recognized by CD8+ T cells in vivo. To identify such peptides, we evaluated HLA-A*02+ melanoma patients immunized to a polyvalent vaccine co...
Topics
- Alleles
- Antigens, Neoplasm
- CD8-Positive T-Lymphocytes
- Cancer Vaccines
- Disease-Free Survival
- HLA-A2 Antigen
- Humans
- Immunization
- Intramolecular Oxidoreductases
- MART-1 Antigen
- Melanoma
- Membrane Glycoproteins
- Monophenol Monooxygenase
- Neoplasm Proteins