Article
A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.
Biological psychiatry - 1 Apr 2000
Heinz A, Jones D W, Mazzanti C, Goldman D, Ragan P, Hommer D, Linnoila M, Weinberger D R
Abstract excerpt
BACKGROUND: Genetic variation of the promoter for the serotonin transporter (5-HTT) gene has been associated with its functional capacity. In vitro, carriers of a short allele (s-carriers) of the 5-HTT promoter display significant reduction in 5-HTT capacity. Dysfunction of 5-HTT has been observed in alcoholic individuals. We assessed whether the allelic constitution of the 5-HTT gene is associated with reduced...
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