Article
Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.
The American journal of psychiatry - 1 Mar 2004
van Dyck Christopher H, Malison Robert T, Staley Julie K, Jacobsen Leslie K, Seibyl John P, Laruelle Marc, Baldwin Ronald M, Innis Robert B, Gelernter Joel
Abstract excerpt
OBJECTIVE: A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro studies of...
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