Article
Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jan 2005
Javors Martin A, Seneviratne Chamindi, Roache John D, Ait-Daoud Nassima, Bergeson Susan E, Walss-Bass M Consuelo, Akhtar Fatema Z, Johnson Bankole A
Abstract excerpt
Expression rates of long (L) and short (S) alleles of the serotonin (5-HT) transporter (5-HTT) gene have been shown to differ under various circumstances. We compared 5-HTT uptake (function) level and paroxetine binding (density) in platelets of alcoholics as indices of 5-HTT expression rate among LL, LS, and SS genotypes. Concentration curves of [3H]5-HT and [3H]paroxetine were used to quantify the equilibrium...
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