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Article

Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Mar 2016

Thompson Miles D, Kenna George A

Abstract excerpt

SLC6A4, the gene encoding the serotonin transporter protein (5-HTT), has been extensively examined as a risk factor for alcohol dependence (AD). More recently, variability in the transporter gene was identified to be a potential moderator of treatment response to serotonergic medications such as ondansetron and sertraline. There is an insertion-deletion polymorphism in the promoter region (5-HTTLPR) of the...

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Source

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Identifiers

PMID: 26311211
DOI: 10.1093/alcalc/agv090
PMCID: PMC4755552

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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