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Article

Accounting for structural properties and nucleotide co-variations in the quantitative prediction of binding affinities of protein-DNA interactions.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2006

Gunewardena Sumedha, Zhang Zhaolei

Abstract excerpt

We describe a quantitative model for predicting the binding affinity of protein-DNA interactions. The described model is based on templates capable of providing a global representation of the modelled transcription factor (TF) binding sites. Templates can capture non independent nucleotide variations and structural properties present in these sites. Tests carried out on the p50p50 and p50p65 variants of the...

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PMID: 17094254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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