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Article

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

Nucleic acids research - 1 Jul 2010

Littler D R, Alvarez-Fernández M, Stein A, Hibbert R G, Heidebrecht T, Aloy P, Medema R H, Perrakis A

Abstract excerpt

FoxM1 is a member of the Forkhead family of transcription factors and is implicated in inducing cell proliferation and some forms of tumorigenesis. It binds promoter regions with a preference for tandem repeats of a consensus 'TAAACA' recognition sequence. The affinity of the isolated FoxM1 DNA-binding domain for this site is in the micromolar range, lower than observed for other Forkhead proteins. To explain...

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Share to Consensus Sequence
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Protein Multimerization

Share to Protein Structure, Secondary

Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 20360045
DOI: 10.1093/nar/gkq194
PMCID: PMC2910063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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