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Article

Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors.

Journal of hepatology - 1 Mar 2000

Wright-Minogue J, Yao N, Zhang R, Butkiewicz N J, Baroudy B M, Lau J Y, Hong Z

Abstract excerpt

BACKGROUND/AIMS: Hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease requires NS4A as a cofactor. This cofactor activity has been mapped to the central region of NS4A which interacts with the N-terminus of NS3 protease. To investigate whether this interaction is conserved among different genotypes of HCV cross-genotypic characterization were performed to delineate the importance of NS4A cofactor...

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Source

Identifiers

PMID: 10735621
DOI: 10.1016/s0168-8278(00)80402-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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