A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.

doi:10.1128/JVI.69.7.4373-4380.1995

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Article

A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.

Journal of virology - 1 Jul 1995

Lin C, Thomson J A, Rice C M

Abstract excerpt

A virus-encoded serine proteinase mediates four site-specific cleavages in the hepatitis C virus polyprotein. In addition to the catalytic domain, which is located in the N-terminal one-third of nonstructural protein NS3, the 54-residue NS4A protein is required for cleavage at some but not all si...

Topics

Amino Acid Sequence
Molecular Sequence Data
Mutation
Octoxynol
Serine Endopeptidases
Viral Nonstructural Proteins

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