Article
Genetic and catalytic efficiency structure of an HCV protease quasispecies.
Hepatology (Baltimore, Md.) - 1 Apr 2007
Franco Sandra, Parera Mariona, Aparicio Ester, Clotet Bonaventura, Martinez Miguel Angel
Abstract excerpt
UNLABELLED: The HCV nonstructural protein (NS)3/4A serine protease is not only involved in viral polyprotein processing but also efficiently blocks the retinoic-acid-inducible gen I and Toll-like receptor 3 signaling pathways and contributes to virus persistence by enabling HCV to escape the interferon antiviral response. Therefore, the NS3/4A protease has emerged as an ideal target for the control of the disease...
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