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Article

Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.

Journal of viral hepatitis - 1 May 2011

Morikawa K, Lange C M, Gouttenoire J, Meylan E, Brass V, Penin F, Moradpour D

Abstract excerpt

Hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) is a complex composed of NS3 and its cofactor NS4A. It harbours serine protease as well as NTPase/RNA helicase activities and is essential for viral polyprotein processing, RNA replication and virion formation. Specific inhibitors of the NS3-4A protease significantly improve sustained virological response rates in patients with chronic hepatitis C when...

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Share to Adaptor Proteins, Vesicular Transport
Share to Hepatitis C, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Proteins

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Source

Identifiers

PMID: 21470343
DOI: 10.1111/j.1365-2893.2011.01451.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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