Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of amino acid variants in the hepatitis C virus non-structural protein 4A.

The Tohoku journal of experimental medicine - 1 Jul 2009

Bermúdez-Aguirre Alejandro Daniel, Padilla-Noriega Luis, Zenteno Edgar, Reyes-Leyva Julio

Abstract excerpt

Chronic infections by hepatitis C virus (HCV) are a major cause of cirrhosis and hepatic cancer. The replication of HCV involves translation and proteolytic processing of polyproteins. The HCV single-stranded RNA encodes a single polyprotein of C/E1/E2/p7/NS2/NS3/NS4A/NS4B/NS5A/NS5B. The structural proteins, C, E1, E2, and p7, arise from the viral polyprotein by host proteases. Cleavage at the non-structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Amino Acids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Hepacivirus

Share to Polyproteins

Share to Recombinant Fusion Proteins

Share to Sequence Homology, Amino Acid

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 19561386
DOI: 10.1620/tjem.218.165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of amino acid variants in the hepatitis C virus non-structural protein 4A.PMID 19561386Read ↗

A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.Semantic proximity Read ↗

New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.Semantic proximity Read ↗

NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b.Semantic proximity Read ↗

Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.Semantic proximity Read ↗

The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A.Semantic proximity Read ↗

Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors.Semantic proximity Read ↗

Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins.Semantic proximity Read ↗

Molecular models of NS3 protease variants of the Hepatitis C virus.Semantic proximity Read ↗

A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.Semantic proximity Read ↗

Natural presence of NS3 protease R155K hepatitis C virus variants with decreased sensitivity to protease inhibitors.Semantic proximity Read ↗

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.Semantic proximity Read ↗

Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.